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KMID : 0363219920300040529
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Korean Journal of Dermatology
1992 Volume.30 No. 4 p.529 ~ p.534
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Hydrochlorthiazide-induce Phototoxic Reaciton
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Abstract
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A 49-year-old male had erythematous to rusky red papules, indurated plaques and lichenified patches with hyperpigmentation on sun-exposed areas for 6 years. Phototest revealed the decreased minimal erythemal dose to UVA (10J/㎠). Photopatch test
with 5%
trandate(r) ointment, 5% hydrochlorthiazide ointment and vaseline as a control were all negative. Two weeks after cessation of Trandate(r), an oral challenge of hydrochlorthiazide followed by phototest was performed resulting in exacerbtion of
skin
lesions and photosensitivity with a decreased MED to UVA (10J/㎠) again. After the cessation of Trandate(r) containing hydrochlorthiazide, the skin lesions were improved with complete loss of photosensitivity. but, improvement of the infiltrated
or
lichemified plaques were delayed. Presenile cataract previously noted in the patient seemed to be related to his longstanding intake of hydrochlorthiazide. (Kor J Dermatol 1992;30 (4) : 529-534)
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